Probiotics for brain health
Unlock the potential of the gut-brain axis
The gut-brain axis is a two-way signaling system between the gastrointestinal (GI) tract and central nervous system that is shown to influence mood, cognitive function and more. Growing research shows that brain function can be impacted by the gut microbiota.
Disruptions to the gut microbiota composition – known as dysbiosis – dysregulate the pathways connecting the gut-brain axis. This can disturb the balance of the central nervous system; causing changes to the blood-brain barrier’s permeability and increasing the risk of neuroinflammation.1,2,3,4,5 The impact of gut microbiome dysbiosis has been linked to several neuroinflammatory conditions and mood disorders.6,7,8,9,10,11 This is creating an opportunity to develop microbiome-supporting solutions targeted towards brain health.12,13
Due to their positive influence on the gut microbiome, specific probiotic strains have been proposed to indirectly support cognitive function and mood. For this reason, there is a growing number of innovations in the space targeting stress and anxiety, as well as disorders like ADHD (attention deficit hyperactivity disorder) and autism. Our portfolio of cognitive probiotic solutions is proven to enhance a number of mind functions, including memory, concentration and more.
Probiotic solutions for Cognitive health
Mindbiome®
1 billion CFU/dose
Indications
- Stress and anxiety
- Emotional wellbeing
- Memory and cognition
- To sleep and rest better
Probiotic Strains
- L plantarum DR7
Formats
Capsules, sticks
- Clarke G, Grenham S, Scully P, Fitzgerald P, Moloney RD, Shanahan F, et al. The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol Psychiatry (2013).
- Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell (2015) 161:264–76.
- De Vadder F, Kovatcheva-Datchary P, Goncalves D, Vinera J, Zitoun C, Duchampt A, et al. Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. Cell (2014) 156:84–96.
- Kim S, Kim H, Yim YS, Ha S, Atarashi K, Tan TG, et al. Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. Nature (2017) 549:528–32.
- Sharon G, Sampson TR, Geschwind DH, Mazmanian SK. The Central Nervous System and the Gut Microbiome. Cell (2016) 167:915–32.
- Singh V, Roth S, Llovera G, Sadler R, Garzetti D, Stecher B, et al. Microbiota dysbiosis controls the neuroinflammatory response after stroke. J Neurosci (2016) 36:7428–40.
- Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell (2013) 155:1451–63.
- Valles-Colomer M, Falony G, Darzi Y, Tigchelaar EF, Wang J, Tito RY, et al. The neuroactive potential of the human gut microbiota in quality of life and depression. Nat Microbiol (2019) 4:623–32.
- Zheng P, Zeng B, Liu M, Chen J, Pan J, Han Y, et al. The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice. Sci Adv (2019) 5:1–12.
- Haran JP, Bhattarai SK, Foley SE, Dutta P, Ward DV, Bucci V, et al. crossm Alzheimer‘s Disease Microbiome Is Associated with. mBio (2019) 10:1–14.
- Inserra A, Rogers GB, Licinio J, Wong ML. The Microbiota-Inflammasome Hypothesis of Major Depression. BioEssays (2018) 40:1–11.
- Mayer, E. A. Gut feelings: The emerging biology of gut-“brain communication. Nature Reviews Neuroscience vol. 12 453–466 (2011).
- Romijn, J. A, Corssmit, E. P., Havekes, L. M. & Pijl, H. Gut-brain axis. Current Opinion in Clinical Nutrition and Metabolic Care vol. 11 518–521 (2008).
