Probiotic formula for the treatment of infantile colic, which significantly reduces excessive crying in colicky infants according to clinical data.
Excessive crying syndrome, commonly referred as infant colic, varies from 5% to 20% (or even 40%) and it is considered one of the most frequents causes of visit to pediatrician in the first 4 months of life. Ethiology: Although many causes have been proposed, the role of intestinal microflora has been growing in importance.
WHY PROBIOTICS WORK BETTER?
The effectiveness of probiotics is attributed to:
— The ability to displace bacterial pathogens.
— The induction of the production of IL-10, an antiinflammatory cytokine.
— Homofermentative strains do not produce gas, as opposed to other bacteria.
Pediococcus pentosaceus CECT 8330
Bifidobacterium longum CECT 7894
Patented probiotic strains by WO2015018883A2
AB-Kolicare probiotic strains have been specifically selected as the ones with the best performance in alleviating excessive crying syndrome in infants.
The study was designed as a prospective, multicenter, randomized, double-blind and controlled by placebo clinical trial. This pilot study comprised 20 infants with a daily crying duration between 60-240 min/day (mean 100 min/day) who were allocated to one of the following treatments for 14 days: a) 1.00E+09 CFUs (50% strain 1 and 50% strain 2) per day administered as pediatric drops 30 minutes before feeding, b) placebo administered in the same way. A trend towards a greater reduction in daily crying time was observed in the probiotic group compared to placebo (81.0 ± 11.2 vs 54.1 ± 8.6 reduction in minutes per day, respectively; P=0.083). Similarly, reduction in crying time per episode (episode duration) was greater in AB-KOLICARE group (22.5 ± 8.2 min/episode in AB-KOLICARE vs. 8.7 ± 4.4 min/episode in placebo group).
- Strains in the formula selected from in vitro and in vivo models
- Absence of gas production
- Trial efficacy demonstrated both in breastfed and formula-fed infants
- Effects observed in 2 weeks of treatment
- AB-Kolicare targets a broader market (new definition of infant colic)